解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:UNLABELLED:Triple A syndrome is a rare, autosomal recessive cause of adrenal failure. Additional features include alacrima, achalasia of the esophageal cardia, and progressive neurodegenerative disease. The AAAS gene product is the nuclear pore complex protein alacrima-achalasia-adrenal insufficiency neurological disor...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1241
更新日期:2013-09-01 00:00:00
abstract::In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1133
更新日期:2013-09-01 00:00:00
abstract::Cachexia, defined as an involuntary weight loss ≥ 5%, is a serious and dose-limiting side effect of chemotherapy that decreases survival in cancer patients. Alterations in lipid metabolism are thought to cause the lipodystrophy commonly associated with cachexia. Ghrelin has been proposed to ameliorate the alterations ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1179
更新日期:2013-09-01 00:00:00
abstract::Vitellogenin (Vg) is a major yolk protein precursor in numerous oviparous animals. Numerous studies in bilateral oviparous animals have shown that Vg sequences are conserved across taxa and that Vgs are synthesized by somatic-cell lineages, transported to and accumulated in oocytes, and eventually used for supporting ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1086
更新日期:2013-09-01 00:00:00
abstract::In the present study, we have investigated the cellular mechanisms of androgen-induced antral follicular growth arrest and the possible involvement of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) in this process, using a chronically androgenized rat model. We hypothesize that hyperandrogenism induces a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1001
更新日期:2013-08-01 00:00:00
abstract::In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testoster...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1120
更新日期:2013-08-01 00:00:00
abstract::Task3 K(+) channels are highly expressed in the adrenal cortex and contribute to the angiotensin II and K(+) sensitivity of aldosterone-producing glomerulosa cells. Adult Task3(-/-) mice display a partially autonomous aldosterone secretion, subclinical hyperaldosteronism, and salt-sensitive hypertension. Here, we inve...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1101
更新日期:2013-08-01 00:00:00
abstract::Recent evidence has linked mitochondrial dysfunction and DNA damage, increased oxidative stress in skeletal muscle, and insulin resistance (IR). The purpose of this study was to determine the role of the DNA repair enzyme, human 8-oxoguanine DNA glycosylase/apurinic/apyrimidinic lyase (hOGG1), on palmitate-induced mit...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1076
更新日期:2013-08-01 00:00:00
abstract::As we previously showed, we have synthesized a new family of 17β-estradiol-platinum(II) hybrids. Earlier studies revealed the VP-128 hybrid to show high efficiency compared with cisplatin toward hormone-dependent breast cancer cells. In the present research, we have studied the antitumor activity of VP-128 in vitro an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1083
更新日期:2013-07-01 00:00:00
abstract::Hypothalamic inflammation and gliosis are proposed to participate in the pathogenesis of high-fat diet-induced obesity. Because other factors and nutrients also induce weight gain and adiposity, we analyzed the inflammatory and glial responses to a sucrose (S)-enriched diet. Neonatal overnutrition (NON) exacerbates we...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2196
更新日期:2013-07-01 00:00:00
abstract::Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patien...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1096
更新日期:2013-07-01 00:00:00
abstract::Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a posttranscriptional regulator of genes that are essential for spermatid elongation and completion of spermatogenesis. It also prevents Leydig cells (LCs) from gonadotropin overstimulation of androgen production. In transgenic (Tg) mice carrying deletions...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2230
更新日期:2013-06-01 00:00:00
abstract::Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2201
更新日期:2013-06-01 00:00:00
abstract::After reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal str...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2131
更新日期:2013-05-01 00:00:00
abstract::TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2074
更新日期:2013-05-01 00:00:00
abstract::Puberty in primates is timed by 2 hypothalamic events: during late infancy a decline in pulsatile GnRH release occurs, leading to a hypogonadotropic state that maintains quiescence of the prepubertal gonad; and in late juvenile development, pulsatile GnRH release is reactivated and puberty initiated, a phase of develo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2154
更新日期:2013-05-01 00:00:00
abstract::Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2066
更新日期:2013-04-01 00:00:00
abstract::The maternal skeleton resorbs during lactation to provide calcium to milk and the lost mineral content is restored after weaning. The changes are particularly marked in Ctcgrp null mice, which lose 50% of spine mineral content during lactation but restore it fully. The known calciotropic hormones are not required for ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1931
更新日期:2013-04-01 00:00:00
abstract::Osteocalcin, a synthetic osteoblast-specific protein, has recently emerged as an important regulator of energy metabolism, but the underlying mechanisms are not fully understood. In the present study, mice fed a high-fat diet and receiving osteocalcin showed reduced body weight gain, less fat pad gain, and improved in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2144
更新日期:2013-03-01 00:00:00
abstract::Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1855
更新日期:2013-03-01 00:00:00
abstract::In this study we used live-cell immunocytochemistry and confocal microscopy to study the release from a single vesicle in a simplified system called membrane lawns. The lawns were prepared by exposing differentiated pituitary prolactin (PRL)-secreting cells to a hypoosmotic shear stress. The density of the immunolabel...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2022
更新日期:2013-03-01 00:00:00
abstract::Periodontitis, an inflammatory disease of periodontal tissues, is characterized by excessive alveolar bone resorption. An increase in the receptor activator of nuclear factor-κB ligand (RANKL) to osteoprotegerin (OPG) ratio is thought to reflect the severity of periodontitis. Here, we examined alveolar bone loss in OP...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1928
更新日期:2013-02-01 00:00:00
abstract::Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1607
更新日期:2013-02-01 00:00:00
abstract::Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1813
更新日期:2013-02-01 00:00:00
abstract::Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1421
更新日期:2013-02-01 00:00:00
abstract::Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1559
更新日期:2013-01-01 00:00:00
abstract::In the gonads and adrenal glands, the transient increase in steroidogenesis after hormonal stimulation requires modulation of steroidogenic acute regulatory protein (Star) expression and activity in a tightly regulated process involving cAMP and Ca(2+). In Leydig cells, the cAMP and Ca(2+) pathways account for most if...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1767
更新日期:2013-01-01 00:00:00
abstract::Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1693
更新日期:2013-01-01 00:00:00
abstract::The adrenal medulla contains fenestrated capillaries that allow catecholamines and neuropeptides secreted by adrenal chromaffin cells (ACCs) to readily access the circulation. These capillaries may also allow bacterial products to enter the adrenal medulla and interact with ACCs during infection. One potential mediato...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1534
更新日期:2013-01-01 00:00:00
abstract::In mice, GH levels rise in response to short-term fasting or starvation (food restriction to 40% of ad libitum intake), similar to that which occurs in humans in response to fasting or anorexia. Recent studies using acyl-ghrelin knockout mice have suggested that the rise in GH during food restriction is essential to s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1849
更新日期:2013-01-01 00:00:00
abstract::Three members of the progestin and adipoQ receptor (PAQR) family, PAQR-7, PAQR-8, and PAQR-5 [membrane progesterone (P4) receptor (PR) (mPR)α, mPRβ, and mPRγ], function as plasma mPRs coupled to G proteins in mammalian cells, but the characteristics of two other members, PAQR6 and PAQR9 (mPRδ and mPRε), remain unclear...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1772
更新日期:2013-01-01 00:00:00
abstract::Differentiation of endometrial stromal cells into decidual cells is a prerequisite for successful embryo implantation. Our previous studies in the mouse have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ superfamily, is essential for this differentiation process. BMP2 is markedly in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1585
更新日期:2013-01-01 00:00:00
abstract::Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and steroidogenic enzym...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-2065
更新日期:2012-12-01 00:00:00
abstract::Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1611
更新日期:2012-12-01 00:00:00
abstract::Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis affecting the reproductive functions. We have shown previously that transgenic female mice overexpressing human chorionic gonadotropin β...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1393
更新日期:2012-12-01 00:00:00
abstract::Hypothalamic neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons act to sense and coordinate the brain's responses to metabolic cues. One neuronal network that is very sensitive to metabolic status is that controlling fertility. In this study, we investigated the impact of neuropeptides released by NPY and POM...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1470
更新日期:2012-11-01 00:00:00
abstract::3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1254
更新日期:2012-11-01 00:00:00
abstract::Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids act directly on cardiomyocytes are poorly understood. To explore the role of glucocorticoid signaling in the heart, we used rat embryonic H9C2 cardiomyocytes and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1563
更新日期:2012-11-01 00:00:00
abstract::Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in this region. In the present study, we addressed the hypothesis t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1739
更新日期:2012-11-01 00:00:00
abstract::Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1331
更新日期:2012-10-01 00:00:00